Dietary BCAA supplementation has been used clinically to aid in the recovery of burn victims.
A 2006 paper suggests that the concept of nutrition supplemented with all BCAAs for burns, trauma
, and sepsis should be abandoned for a more promising leucine-only-supplemented nutrition that requires
further evaluation.  Dietary BCAAs are also used in the treatment of some cases of hepatic encephalopathy.
A 2011 study of morbidly obese subjects with type-2 diabetes suggested that the reduction in blood BCAAs resulting
from gastric bypass surgery may be associated with improvement in blood sugar regulation. The mechanism remains
A 2012 study suggests genetic mutations in some autism models lead to altered branched chain amino acid
pathways that might be normalized with dietary supplementation.
Cota et al. (1) demonstrated in 2006 that BCAAs, particularly leucine, also affect the mTOR pathway
, signaling two regions of the brain. These signals decrease food intake and increase basic metabolic rate
. These results led to a clinical trial by Ordman (3) to develop a nutraceutical method for controlling weight
gain in humans. The potential of nutrients to signal changes in metabolism is exemplified by how BCAAs may
increase muscle repair, but it is important to be aware how it may also decrease appetite.
Certain studies suggested a possible link between a high incidence of amyotrophic lateral sclerosis among
professional American football players and Italian soccer players, and certain sports supplements including
BCAAs. In mouse studies, BCAAs were shown to cause cell hyper-excitability resembling that usually
observed in ALS patients. The proposed underlying mechanism is that cell hyper-excitability results in increased
calcium absorption by the cell and thus brings about cell death, specifically of neuronal cells which have particularly
low calcium buffering capabilities. Yet any link between BCAAs and ALS remains to be fully established.
While BCAAs can induce a hyperexcitability similar to the one observed in mice with ALS, current work does
not show if a BCAA-enriched diet, given over a prolonged period, actually induces ALS-like symptoms.